HMPV is not a new virus. It is a well-known pathogen to infectious disease specialists and has been circulating in most countries, including India, for quite some time. As per the CDC, HMPV has a seasonal pattern, circulating in late winter and spring in temperate regions. 

Prevalence

Human metapneumovirus (HMPV) is a respiratory virus that can cause severe lower respiratory tract disease with symptoms similar to common cold or flu symptoms.

  • HMPV is estimated to cause 5%–25% of respiratory infections in infants and children (2–5 years) and 1.5%–10.5% in adults. 
  • In children, HMPV is responsible for 5%–15% of hospitalizations for LRTI. 
  • In adult populations, HMPV is responsible for up to 11% of hospitalizations for acute respiratory illness, particularly in adults with underlying heart or lung disease.

Who Is At Risk?

HMPV can infect anyone, but it poses a higher risk to:

  • Older adults, particularly those over 65.
  • Children under 5 years old, especially infants.
  • Individuals with weakened immune systems or chronic respiratory conditions like asthma or COPD.

How HMPV Spreads?

  • Droplets from coughing or sneezing.
  • Close contact, such as touching or shaking hands.
  • Contaminated surfaces, followed by touching the mouth, nose, or eyes.

Prevention Strategies

  • Wash hands frequently with soap and water for at least 20 seconds.
  • Avoid touching your face with unwashed hands.
  • Wear masks in crowded places during outbreaks.
  • Stay home when sick to prevent spreading the virus.
  • Basic cough etiquette 
  • Regularly clean frequently touched surfaces.

Please Note: Currently, it is not a notifiable disease under IDSP. 

Diagnosing Tests

  • Nucleic acid amplification tests (NAATs) to detect viral genetic material.
  • Immunofluorescence or enzyme immunoassays to identify viral antigens.
  • Routine testing is rare unless symptoms are severe or there’s an outbreak.
  • Confirmation with Biofire Panel Test, which is a high-cost test.

Treatment

There is no specific antiviral treatment or vaccine for HMPV – focus on alleviating symptoms

  • Stay hydrated and rest.
  • Use over-the-counter (OTC) medications for pain, congestion, and fever.
  • Severe cases may require hospitalization for oxygen therapy or intravenous fluids.
  • Only contact isolation is recommended. No competent agency has recommended respiratory isolation. Healthcare providers should take standard precautions like any other ailment

For most, HMPV resolves within a week, but young children, older adults, and those with underlying conditions should remain vigilant. 

Contact A Healthcare Provider If Symptoms

  • Worsen after a few days.
  • Include difficulty breathing or cyanosis (bluish skin).
  • Occur alongside chronic health conditions like asthma or COPD.

Expert Opinions

As per Global Experts: Based on a probabilistic analysis, the current viral spread is unlikely to result in a COVID like crisis. The reasons for this assessment are twofold:

  • Seasonal and Transient Nature- This inherent characteristic of the viruses suggests a natural decline in cases after a short period, unlike the sustained transmission observed with COVID-19’s Delta variant  
  • Healthcare System Resilience:  The healthcare system’s capacity to adapt to seasonal illnesses has been demonstrated historically, and the current situation is expected to be managed within these adaptive responses.

References: Cleveland Clinic, CDC, ICMR, NHM, IDSP Guidelines

While the situation warrants monitoring and appropriate healthcare responses, the probability of a crisis on the scale of the Delta variant pandemic is low.

Dr. Maheshkumar Lakhe

Consultant-Infectious Diseases

Sahyadri Hospitals, Pune

 

Dr. Raman Gaikwad

Consultant-Infectious Diseases

Sahyadri Hospitals, Pune

 

Dr. Vaibhav Dudhat

Consultant-Microbiology

Sahyadri Hospitals, Pune

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