Home > Genetics
Welcome to Meningioma Database
This database is an outcome of the work done by a team of Specialists encompassing Neurosurgeons, Histopathologists and Cytogeneticists. This study is deduced from the who patientsunderwent treatment for meninigiomas at our Hospitals.
Patient Demographic Details
| Age (Years) | ≤20 | 21-40 | 41-60 | >60 | |
| Total 197 | 07 | 56 | 93 | 41 | |
| Gender | |||||
| Male | Female | ||||
| 72(37%) | 125 (63%) | ||||
| Side of Tumor (Intra-cranial) | |||||
| Left | Right | CV Junction | |||
| 114 | 65 | 05 | |||
| Site of Tumor | |||||
| Base of Skull | Surfaces of brain | Intraventricular | Spinal | ||
| 66 | 112 | 06 | 13 | ||
Grade I Meningioma
| Total | Grade I |
| 197 | 181 (92%) |
Benign grade I meningiomas are slow growing tumours which include histological variants such as meningothelial, fibrous and transitional meningiomas. Grade I meningiomas present with whorl formation giving rise to concentric rings of hyalinization and psammoma bodies. After complete surgical resection, 5% of Grade I benign meningiomas are known to recur after 5 years.
Histopathology of different variants of benign or WHO Grade I Meningioma
A. Meningothelial B. Transitional C. Fibrous D. Angiomatous E. Microcystic F. Psammomatous G. Secretory H. Lymphoplasmacyte-rich I. Metaplastic
Grade II Meningioma
| Total | Grade II |
| 197 | 8 (4%) |
Grade II meningiomas are atypical meningiomas showing increased cellularity, high nuclear to cytoplasmic ratio, prominent nucleoli, sheet-like growth and foci of spontaneous necrosis and at times can be brain invasive. These are associated with a significantly higher risk of local tumour recurrence than benign meningiomas, even after gross total resection.
Histopathology of different variants of benign or WHO Grade I Meningioma
A. Clear Cell B. Chondroid
Grade III Meningioma
| Total | Grade III |
| 197 | 8 (4 %) |
Grade III meningiomas, also known as anaplastic meningiomas are classified as associated with a poor prognosis of a median survival time of less than 2 years after diagnosis. They account for 1-3% of all meningioma cases. These tumours are clinically more aggressive, can infiltrate neighbouring tissues and form metastatic deposits.
Histopathology of variants of Anaplastic or WHO Grade III Meningioma
A. Rhabdoid B. Papillary
Genetic Markers as Indicators of Prognosis
| Genetic marker studied | Findings | Prognosis |
| Chromosome 1p | Deleted | Poor, indicating recurrence |
| Chromosome 14q | Deleted | Poor, early relapse |
| p16 gene | Deleted | Poor, aggressive tumour |
| Deletions of Genetic Markers (Total 32) | |||||||||
| Genetic Marker deletion | Genetic Markers Co-deletion | ||||||||
| 1p | p16 | 14q | 1p and 14q together | 1p & p16 | 14q & p16 | ||||
| 8 | 8 | 10 | 4 | 1 | 1 | ||||
Representative FISH images of 1p, 14q and p16 gene
(The bars in all images are equal to 50 µm.)
(The bars in all images are equal to 50 µm.)
Meningioma Recurrence
Association of Genetic Marker abnormalities in recurrent and non-recurrent meningioma samples compared to Histology Grades.
| A. Genetic Marker Deletions compared with Histopathology Grade in Recurrent Samples (n=8) | |||||||||
| Histopathology Grade | Genetic Marker deletion | Genetic Markers Co-deletion | |||||||
| 1p | p16 | 14q | 1p & 14q | 1p & p16 | 14q & p16 | ||||
| I | 2 | 3 | 0 | 1 | 0 | 0 | |||
| II | 0 | 0 | 0 | 0 | 0 | 0 | |||
| III | 0 | 1 | 0 | 0 | 0 | 1 | |||
Association of Genetic Marker abnormalities in non-recurrent meningioma samples compared to Histopathology Grades
| B. Genetic Marker Deletions compared with Histopathology Grade in Non-Recurrent Samples (n=24) | |||||||||
| Histopathology Grade | Genetic Marker deletion | Genetic Marker Co-deletion | |||||||
| 1p | p16 | 14q | 1p & 14q | 1p & p16 | 14q & p16 | ||||
| I | 6 | 4 | 7 | 3 | 0 | 0 | |||
| II | 0 | 0 | 2 | 0 | 0 | 0 | |||
| III | 0 | 0 | 1 | 0 | 1 | 0 | |||
Association of genetic marker abnormalities in recurrent meningioma samples (n=14) (at significance level of 5%)
| Genetic Marker | 1p deleted | 1p not deleted |
| Recurrence (Total no. 14) | 3 | 11 |
| ‘p’ value (<0.05) | 0.054 | |
| Genetic Marker | p16 deleted | p16 not deleted |
| Recurrence (Total no. 14) | 5 | 9 |
| ‘p’ value (<0.05) | <0.001 | |
| Genetic Marker | 14q deleted | 14q not deleted |
| Recurrence (Total no. 14) | 2 | 12 |
| ‘p’ value (<0.05) | 0.289 | |