Home > Genetics

Welcome to Meningioma Database

This database is an outcome of the work done by a team of Specialists encompassing Neurosurgeons, Histopathologists and Cytogeneticists. This study is deduced from the who patientsunderwent treatment for meninigiomas at our Hospitals.

Patient Demographic Details

Age (Years) ≤20 21-40 41-60 >60
Total 197 07 56 93 41
Gender
Male Female
72(37%) 125 (63%)
Side of Tumor (Intra-cranial)
Left Right CV Junction
114 65 05
Site of Tumor
Base of Skull Surfaces of brain Intraventricular Spinal
66 112 06 13

Grade I Meningioma

Total Grade I
197 181 (92%)
Benign grade I meningiomas are slow growing tumours which include histological variants such as meningothelial, fibrous and transitional meningiomas. Grade I meningiomas present with whorl formation giving rise to concentric rings of hyalinization and psammoma bodies. After complete surgical resection, 5% of Grade I benign meningiomas are known to recur after 5 years.

Histopathology of different variants of benign or WHO Grade I Meningioma

A. Meningothelial B. Transitional C. Fibrous D. Angiomatous E. Microcystic F. Psammomatous G. Secretory H. Lymphoplasmacyte-rich I. Metaplastic

Grade II Meningioma

Total Grade II
197 8 (4%)
Grade II meningiomas are atypical meningiomas showing increased cellularity, high nuclear to cytoplasmic ratio, prominent nucleoli, sheet-like growth and foci of spontaneous necrosis and at times can be brain invasive. These are associated with a significantly higher risk of local tumour recurrence than benign meningiomas, even after gross total resection.

Histopathology of different variants of benign or WHO Grade I Meningioma

A. Clear Cell B. Chondroid

Grade III Meningioma

Total Grade III
197 8 (4 %)
Grade III meningiomas, also known as anaplastic meningiomas are classified as associated with a poor prognosis of a median survival time of less than 2 years after diagnosis. They account for 1-3% of all meningioma cases. These tumours are clinically more aggressive, can infiltrate neighbouring tissues and form metastatic deposits.

Histopathology of variants of Anaplastic or WHO Grade III Meningioma

A. Rhabdoid B. Papillary

Genetic Markers as Indicators of Prognosis

Genetic marker studied Findings Prognosis
Chromosome 1p Deleted Poor, indicating recurrence
Chromosome 14q Deleted Poor, early relapse
p16 gene Deleted Poor, aggressive tumour
Deletions of Genetic Markers (Total 32)
Genetic Marker deletion Genetic Markers Co-deletion
1p p16 14q 1p and 14q together 1p & p16 14q & p16
8 8 10 4 1 1
Representative FISH images of 1p, 14q and p16 gene
(The bars in all images are equal to 50 µm.)

Meningioma Recurrence

Association of Genetic Marker abnormalities in recurrent and non-recurrent meningioma samples compared to Histology Grades.
A. Genetic Marker Deletions compared with Histopathology Grade in Recurrent Samples (n=8)
Histopathology Grade Genetic Marker deletion Genetic Markers Co-deletion
1p p16 14q 1p & 14q 1p & p16 14q & p16
I 2 3 0 1 0 0
II 0 0 0 0 0 0
III 0 1 0 0 0 1
Association of Genetic Marker abnormalities in non-recurrent meningioma samples compared to Histopathology Grades
B. Genetic Marker Deletions compared with Histopathology Grade in Non-Recurrent Samples (n=24)
Histopathology Grade Genetic Marker deletion Genetic Marker Co-deletion
1p p16 14q 1p & 14q 1p & p16 14q & p16
I 6 4 7 3 0 0
II 0 0 2 0 0 0
III 0 0 1 0 1 0
Association of genetic marker abnormalities in recurrent meningioma samples (n=14) (at significance level of 5%)
Genetic Marker 1p deleted 1p not deleted
Recurrence (Total no. 14) 3 11
‘p’ value (<0.05) 0.054
Genetic Marker p16 deleted p16 not deleted
Recurrence (Total no. 14) 5 9
‘p’ value (<0.05) <0.001
Genetic Marker 14q deleted 14q not deleted
Recurrence (Total no. 14) 2 12
‘p’ value (<0.05) 0.289
Emergency/Ambulance
+91-88888 22222
Emergency/Ambulance
+91-88062 52525
Call Now

Generic selectors
Exact matches only
Search in title
Search in content
page
post